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Negida Research Academy/C5: Systematic Review and Meta-analysis [Arabic]
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C5: Systematic Review and Meta-analysis [Arabic]


Learn the gold-standard methods to conduct systematic reviews and meta-analysis of interventional studies.
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Registration Methods

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If you use PayPal, click on the "Buy Now" button and continue the process through PayPal. After checkout, you will get immediate enrollment in the course. 
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Other Methods?

If you do not use PayPal, fill out this registration form: https://forms.gle/wCoHoJDGS4XorEMM8 and follow the instructions of the course coordinator. He will contact you by email and you will be enrolled manually in the course.
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The following items are covered in the course

โ–ช Why do we need systematic reviews?
โ–ช Types of Systematic Reviews
โ–ช Steps of Systematic Reviews
โ–ช Review question
โ–ช Developing the review criteria
โ–ช How to search the literature
โ–ช Methods of screening
โ–ช Tips for data extraction
โ–ช Quality assessment of RCTs using Cochrane ROB tool
โ–ช PRISMA flow diagram โ€ 
โ–ช Risk of bias figure and risk of bias summary โ€ 
โ–ช Introduction to the Meta-analysis
โ–ช Interpretation of Forest plot
โ–ช Pooling continuous and dichotomous data โ€ 
โ–ช Interpretation of Funnel plot for Assessment of Publication bias
โ–ช Subgroup analysis and Sensitivity analysis โ€ 
โ–ช PRISMA checklist
โ–ช Meta-analysis workshop (3 case scenarios)
โ–ช Estimation of missing data in meta-analysis
โ–ช Meta-regression analysis: concept, procedures, and interpretation โ€ก
โ–ช Cumulative meta-analysis โ€ก
โ–ช Leave one out meta-analysis โ€ก
โ–ช IPD meta-analysis, NMA network meta-analysis (define & example only)

Live Online Lectures

  • The full course is explained by Dr. Negida through 4 live lectures on ZOOM, twice per year, usually in Winter & Summer. 
  • Follow the course contents page - "Live Lectures" section for announcements and links to the sessions of this course.
  • You can join any of the live lectures if you want + PLUS + you can study from the recorded video lectures of the old versions of the course (see below).

Recorded Video Lectures

By joining the course, you are also gaining access to the old versions of the course. 

  • The full course as recorded video lectures of NCRT - Summer 2019 [12 hours]

  • The full course as recorded video lectures of NCRT - Summer 2020 [12 hours]

Course Contents

๐Ÿ”ฅ NEW ๐Ÿ”ฅ Summer 2022

Zoom Link for the Live Lectures
    Recorded Video, Lecture 1 (25 August)
      Recorded Video, Lecture 2 (26 August)
        Recorded Video, Lecture 3 (28 August)
          Recorded Video, Lecture 4 (29 August)

            Archived ๐Ÿ•ต๐Ÿปโ€โ™‚๏ธ Winter 2022

            Zoom Link for the Live Lectures
              Recorded Video, Lecture 1 (3 March)
                Recorded Video Lecture 2 (4 March 2022)
                  Recorded Video, Lecture 3 (5 February)
                    Recorded Video, Lecture 4 (6 March)

                      Archived ๐Ÿ•ต๐Ÿปโ€โ™‚๏ธ Summer 2021

                      Zoom registration link
                        Recorded Lecture 1
                          Recorded Lecture 2
                            Recorded Lecture 3
                              Recorded Lecture 4

                                Archived ๐Ÿ•ต๏ธโ€โ™‚๏ธ Winter 2021

                                Questions & Group Discussions
                                  Lecture 1.mp4
                                  • (1h 21m 46s)
                                  • 237 MB
                                  Q&A before Lecture 2.mp4
                                  • 13 mins
                                  • 115 MB
                                  Lecture 2.mp4
                                  • (1h 38m 30s)
                                  • 375 MB
                                  Q&A before Lecture 3.mp4
                                  • 11 mins
                                  • 49.7 MB
                                  Lecture 3.mp4
                                  • (1h 21m 59s)
                                  • 297 MB
                                  Lecture 4.mp4
                                  • (1h 05m 51s)
                                  • 320 MB

                                  Examples for Systematic Review and Meta-analysis

                                  5 Examples for Systematic Reviews and Meta-analysis published by Dr. Negida (Droxidopa, Coenzyme Q10, HARP, Sunitinib, and DBS Neuropsy).

                                  Other examples are provided here for guidance purposes& were conducted by other researchers (not related to Dr. Negida and his team).
                                  Droxidopa.pdf
                                  • 2.77 MB
                                  Coenzyme Q10.pdf
                                  • 801 KB
                                  DBS Neuropsy.pdf
                                  • 1.69 MB
                                  Sunitinib.pdf
                                  • 884 KB
                                  HARP.pdf
                                  • 841 KB
                                  Neurosurgery.pdf
                                  • 682 KB
                                  Interventional Cardiology.pdf
                                  • 221 KB
                                  Obstetrics.pdf
                                  • 845 KB
                                  Oncology.pdf
                                  • 613 KB
                                  Surgery.pdf
                                  • 582 KB
                                  Dentistry.pdf
                                  • 566 KB
                                  Interventional Cardiology Radiology.pdf
                                  • 17.1 KB
                                  Interventional Cardiology 2.pdf
                                  • 574 KB
                                  Radiology.pdf
                                  • 1.81 MB

                                  Lecture 1

                                  • Introduction to Systematic Review
                                  • Systematic Review vs. Literature Review
                                  • Importance of Systematic Reviews
                                  • Types of Systematic Reviews
                                  • Steps of Systematic Reviews

                                  • ** Step 1 ** Research Question
                                  • ** Step 2 ** Defining the Eligibility Criteria
                                  • ** Step 3 ** Literature Search
                                  • ** Step 4 ** Screening of Records
                                  Lecture notes written by Dr. Negida [theoretical].pdf
                                  • 400 KB
                                  Guide for searching databases & Endnote with Screenshots.pdf
                                  • 1.78 MB
                                  1. Introduction to Systematic review.pdf
                                  • 777 KB
                                  2. Introduction to Meta-analysis.pdf
                                  • 424 KB
                                  3. Review Question and Eligibility Criteria.pdf
                                  • 552 KB
                                  4. Literature Search and Screening.pdf
                                  • 842 KB
                                  PROSPERO; International prospective register of systematic reviews

                                    Homework/Workshop 1: Defining the Research Question & Eligibility Criteria

                                    Assignment 1
                                      Assignement 2
                                        Understanding the Risk of Bias in Randomized Controlled Trials

                                          Lecture 2

                                          • Quality Assessment of RCTs
                                          • Baseline Characteristics Table
                                          • Manuscript Writing According to the PRISMA template
                                          • Introduction to Meta-analysis
                                          • Softwares of Meta-analysis
                                          • Effect Estimates of Meta-analysis
                                          5. Quality Assessment of Randomized Controlled Trials.pdf
                                          • 354 KB
                                          Note: How to Judge the overall Risk of Bias
                                            6. Baseline Characteristics Table.pdf
                                            • 686 KB
                                            7. Meta-analysis Softwares.pdf
                                            • 749 KB
                                            8. Effect Estimates.pdf
                                            • 85.8 KB
                                            9. Before undertaking the analysis.pdf
                                            • 277 KB
                                            Download RevMan Software
                                              When to use the SMD not the MD as the effect estimate
                                                When to use the Odds Ratio (OR) instead of the Risk Ratio (RR)

                                                  Homework/Workshop 2: Assessing the Quality of RCTs according to the ROB

                                                  Assignment 3
                                                    RCT for Quality Assessment - Anderson 2005.pdf
                                                    • 134 KB
                                                    RCT for Quality Assessment - Odekerken2013.pdf
                                                    • 144 KB
                                                    RCT for Quality Assessment - Follett2010.pdf
                                                    • 541 KB
                                                    RCT for Quality Assessment - Rothlind2007.pdf
                                                    • 146 KB
                                                    Assignment 4

                                                      Lecture 3

                                                      9. Before undertaking the analysis.pdf
                                                      • 277 KB
                                                      10. Fixed versus Random effect model.pdf
                                                      • 246 KB
                                                      11. Forest Plot Interpretation.pdf
                                                      • 230 KB
                                                      Interpretation of forest plot (if favored X)
                                                        Interpretation of forest plot (if did not favor any drug)
                                                          Interpretation of sensitivity analysis
                                                            12. Heterogenity.pdf
                                                            • 194 KB

                                                            Homework/Workshop 3: Pooling Data in the Meta-analysis Model using RevMan

                                                            Assignment 3
                                                              Assignment 4
                                                                Assignment 5
                                                                  Activity 1 - Droxidopa OHQ.xlsx
                                                                  • 9.57 KB
                                                                  Activity 2 - AFQ UPDRS.xlsx
                                                                  • 10.8 KB
                                                                  Activity 3 - SOF & VEL for HCV.xlsx
                                                                  • 9.66 KB

                                                                  Lecture 4

                                                                  Download Open Meta[analyst] Software
                                                                    How to Handle Heterogeneity in Meta-analysis
                                                                      Calculate mean and SD from Median IQR.pdf
                                                                      • 901 KB

                                                                      Homework/Workshop 4: Assessing Heterogeneity and Conducting the Subgroup Analysis & Sensitivity Analysis

                                                                      Assignment 6: Assess & interpret the Heterogeneity
                                                                        Assignment 7: Sensitivity Analysis
                                                                          Activity 1 - Droxidopa OHQ.xlsx
                                                                          • 9.57 KB
                                                                          Activity 3 - SOF & VEL for HCV.xlsx
                                                                          • 9.66 KB
                                                                          Activity 2 - AFQ UPDRS.xlsx
                                                                          • 10.8 KB
                                                                          Systematic Review and Meta-analysis QUIZ

                                                                            Zoom Lectures' Videos 2019, 2020, and 2021

                                                                            Zoom lectures links are posted to this section, which includes the following:
                                                                            • Recorded Lectures of previous seasons
                                                                            • Live Lectures of the upcoming seasonย 
                                                                            4 video lectures - Full course - Summer 2019

                                                                              Course Supplements + Advanced resources that are not included in the course

                                                                              Cochrane Handbook of Systematic Reviews and Meta-analysis of Interventions
                                                                                History of meta-analysis.pdf
                                                                                • 152 KB
                                                                                Multiplicity and data extraction errors.pdf
                                                                                • 276 KB
                                                                                Epidemiology and reporting.pdf
                                                                                • 128 KB
                                                                                PRISMA Clist.pdf
                                                                                • 156 KB
                                                                                Outcome reporting bias.pdf
                                                                                • 186 KB
                                                                                Funnel plot.pdf
                                                                                • 616 KB
                                                                                PRISMA E&E.pdf
                                                                                • 624 KB
                                                                                Publication bias.pdf
                                                                                • 317 KB
                                                                                Randomisation and concealed allocation.pdf
                                                                                • 84.9 KB
                                                                                Searching beyond Medline.pdf
                                                                                • 88.2 KB
                                                                                Sample size and data analyses.pdf
                                                                                • 142 KB
                                                                                Attrition bias.pdf
                                                                                • 151 KB
                                                                                Blinding.pdf
                                                                                • 704 KB
                                                                                Constraints on publication rights.pdf
                                                                                • 57.8 KB
                                                                                Study design biases.pdf
                                                                                • 3.19 MB
                                                                                Cohrane Handbook.pdf
                                                                                • 3.45 MB

                                                                                [NOT INCLUDED IN THE COURSE] Stata Do-files for Meta-analysis

                                                                                Templates of Do-files including all Meta-analysis commands on Stata software.

                                                                                These files are used only for STATA software workshops given by Dr. Negida.

                                                                                You do not need to download or use these files unless you are asked by Dr. Negida to do that.
                                                                                generate SD pooled.do
                                                                                • 65 Bytes
                                                                                1.dta
                                                                                • 10.9 KB
                                                                                2.dta
                                                                                • 12.2 KB
                                                                                Metaregression.do
                                                                                • 34 Bytes
                                                                                OHQ.do
                                                                                • 448 Bytes
                                                                                Steprtokinase confunnel.do
                                                                                • 87 Bytes
                                                                                steprokinase mortality metan.do
                                                                                • 460 Bytes
                                                                                Steprtokinase egger's.do
                                                                                • 79 Bytes
                                                                                Steprtokinase Metatrim.do
                                                                                • 97 Bytes
                                                                                steprtokinase mortality meta .do
                                                                                • 493 Bytes
                                                                                subgroup analysis SMD.do
                                                                                • 76 Bytes